Clinical Application of Immune-related Response Criteria in Evaluating Chinese Medical Treatme for Advanced Non-small Cell Lung Cancer / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To evaluate the applicability of immune-related response criteria (irRC) in treating non-small cell lung cancer (NSCLC) by Chinese medicine (CM).</p><p><b>METHODS</b>Totally 97 stage III a-IV NSCLC patients were predominantly treated with comprehensive CM. Curative effects were evaluated by three methods such as Response Evaluation Criteria in Solid Tumors (RECIST), Oncologic Curative Effect Evaluation Criteria of Chinese Medicine in Solid Tumor (draft, abbreviated as CM criteria), and irRC. The correspondency and consistency between irRC, RECIST and CM criteria were analyzed and compared. The objectivity of irRC in evaluating curative effect of Chinese medical treatment for NSCLC was assessed.</p><p><b>RESULTS</b>The correspondency rate of irRC to RECIST was 59. 79% with Kappa value of 0. 379 (U test, P <0. 01). The two criteria had certain correspondence, but with an unsatisfactory consistency. The correspondency rate of irRC to CM criteria rate was 83. 51% with Kappa value of 0.751 (U test, P <0. 01). The two criteria had good correspondence and consistency.</p><p><b>CONCLUSIONS</b>CM criteria had good consistency with CM criteria in evaluating curative effect for Chinese medical treatment of advanced NSCLC. Its results could objectively reflect features and advantages of CM for treating advanced NSCLC.</p>

Integrative medical research thinking on the Constitution-subhealth-disease relation developing axis / 中国中西医结合杂志

In order to explore the objective rule and the key factors in the development of diseases, the process from quantitative change to qualitative change, and from health through sub-health to disease, a new thinking of research, enitled by "Constitution-Subhealth-Disease Relation Developing Axis" is offered by the author. This axis took the CM theory on body constitution as a core, with the coordinates composed of physiological and pathological indices concerning the quantitative changes of illness accumulated under sub-health state. Meanwhile, the key factors for advancing the access and inducing qualitative change of illness were denoted. The orientation of the research is starting from two aspects, horizontally on the crowd possessing the same body constitution, and longitudinally on the same person in different conditions. The research sum-up the general rule of disease occurrence through individually studying the process in persons with different body constitutions, then the commonness of diseases developed from the bottom was explored by applying the outcomes of the foregoing global study on the sorted researches of different constitutions.